PROJECT 3

Synthesizing non-steroidal anti-inflammatory drugs successfully and improving the corroborating efficacy of the yield.
While NSAIDs account for most of the pain relief market, they still possess major contradictory effects due to their interaction with isoenzyme COX-1, which is responsible for regulating the gastric mucosal layer. While the inhibition of inflammatory response is facilitated through the regulated COX-2 enzyme, effects on the constitutively expressed COX-1 can be deleterious. The inhibition of this receptor caused by NSAIDs (especially in immunocompromised or elderly patients) can result in stomach wall exposure and peptic ulceration.
Our dedicated GIOI staff facilitated an investigation into the improved efficacy of metal-NSAID synthesis yield, characterization using infrared spectroscopy and SEM/EDS, solubility testing of synthesized complexes, and evaluation of biological activity via in vitro testing of antioxidant, anti-inflammatory, and anti-protein denaturation capacity.